In captivity a gray wolf can reach 70 kg and live to 15 years old.

There is no reason for large domestic dogs to be short lived except the horrible things that inbreeding has done to them.

Maybe just stop breeding sick dogs on purpose, idk

By how much are we expecting this drug to expand the lifespan of dogs? I read the article and could not find it. Anyone here know?

This is the best summary I could come up with:

The animal pharmaceutical company Loyal announced that the FDA has accepted the development of a drug that could extend the lifespans of large and giant dog breeds.

In a blog post published today, Celia Halioua, the founder and CEO of Loyal, said that the company earned the FDA’s acceptance of the drug.

“In regulatory parlance,” Halioua wrote, “we have completed the technical effectiveness portion of our conditional approval application for LOY-001’s use in large dog lifespan extension.”

Giant dogs are the ones that might make you gawk on the street: Great Danes, Irish wolfhounds, and Anatolian shepherds to name a few.

“At Loyal, we see the short lifespan of big dogs not as inevitable, but as a genetically-associated disease caused by historical artificial selection, and therefore amenable to targeting and treatment with a drug.”

According to Halioua’s post, breeding large dogs for their size caused elevated levels of IGF-1, a hormone that promotes cell growth.

The original article contains 431 words, the summary contains 155 words. Saved 64%. I’m a bot and I’m open source!